TUPE072 - Poster Exhibition
High-risk human papillomavirus infection in anal epithelium among HIV-1 (+) and (-) trans-women and men who have sex with men in the Dominican Republic
R. Paulino1,2, J.C. Tejada2, A. Benitez3, J. Peña2, L. De La Paz2, N. Gomez1, J. Belen4, D. Diaz4, E. Koenig2
1Universidad Iberoamericana-UNIBE, Research Department/ School of Medicine, Santo Domingo, Dominican Republic, 2Instituto Dominicano de Estudios Virológicos, Research, Santo Domingo, Dominican Republic, 3Hospital Moscoso Puello, Pathology, Santo Domingo, Dominican Republic, 4Universidad Iberoamericana-UNIBE, School of Medicine, Santo Domingo, Dominican Republic
Background: After 31 years of first described as the
cause of AIDS, HIV remains as a big tread between Trans-women (TW) and Men who
have sex with Men (MSM). HIV seroprevalence among MSM in the Dominican Republic
is estimated to 11%;
and in TW more than 14-69%. Anal cancer is estimated
in 35 per 100,000 among HIV (-) MSM, and doubled among HIV (+).
Human papillomavirus (HPV) plays an important role in the appearance of anal
Methods: After informed consent
and epidemiological data collection, anal swabs were obtained for HPV genotype
molecular, and a separate swab for
cytological examination in HIV-infected and uninfected MSM and TW. Participants were randomly selected from different communities based on
reported sexual contacts, and to provide informed consent.
HIV free testing was offered and pre and post-counselling were administered.
Results: Two hundred fulfilled the inclusion criteria; TW
represented 35.5% and MSM 64.5%.
HIV seroprevalence was 14.5% in TW, and 60.4% in MSM. (Figure 1) Anal pap smear
with abnormal results were compared based on participants viral status, and among
those MSM HIV (+) the prevalence was 11.5%, and in TW HIV (+) 55.5%,
in MSM HIV (-) was 11.7%, and in TW HIV (-) 4.8%. Comparison of pap abnormalities,
and High-risk HPV (HR-HPV), revealed that in both HIV (+) and (-) TW all were
linked to HR-HPV, with 83.3-88.8% in MSM, and in TW a 100%. (Figure 3)Among these HR-HPV
genotypes, HPV 51 was present in 20% in TW, and 22% in MSM. (Figure 3)
Conclusions: HIV seroprevalence was similar in TW
population as some estimates (CDC, 2011), but slightly greater in MSM. In our study, HIV and abnormal anal pap results in TW was found
exaggeratedly higher with 55.5% among those HIV (+), and only 11.7% in MSM, but
also we noted that the presence of HR-HPV in TW was 100%, compared with a range
of 83.3-88.8% among MSM. The finding of HPV51 prevalence and the finding of
abnormal pap results open a question mark, about if this genotype is the mainly cause of HPV-related
cancer in TW/MSM population.
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