20th International AIDS Conference - Melbourne, Australia


TUPE072 - Poster Exhibition

High-risk human papillomavirus infection in anal epithelium among HIV-1 (+) and (-) trans-women and men who have sex with men in the Dominican Republic

R. Paulino1,2, J.C. Tejada2, A. Benitez3, J. Peña2, L. De La Paz2, N. Gomez1, J. Belen4, D. Diaz4, E. Koenig2

1Universidad Iberoamericana-UNIBE, Research Department/ School of Medicine, Santo Domingo, Dominican Republic, 2Instituto Dominicano de Estudios Virológicos, Research, Santo Domingo, Dominican Republic, 3Hospital Moscoso Puello, Pathology, Santo Domingo, Dominican Republic, 4Universidad Iberoamericana-UNIBE, School of Medicine, Santo Domingo, Dominican Republic

Background: After 31 years of first described as the cause of AIDS, HIV remains as a big tread between Trans-women (TW) and Men who have sex with Men (MSM). HIV seroprevalence among MSM in the Dominican Republic is estimated to 11%[1]; and in TW more than 14-69%. Anal cancer is estimated in 35 per 100,000 among HIV (-) MSM, and doubled among HIV (+). Human papillomavirus (HPV) plays an important role in the appearance of anal malignancies.
Methods: After informed consent and epidemiological data collection, anal swabs were obtained for HPV genotype molecular, and a separate swab for cytological examination in HIV-infected and uninfected MSM and TW. Participants were randomly selected from different communities based on reported sexual contacts, and to provide informed consent. HIV free testing was offered and pre and post-counselling were administered.
Results: Two hundred fulfilled the inclusion criteria; TW represented 35.5% and MSM 64.5%. HIV seroprevalence was 14.5% in TW, and 60.4% in MSM. (Figure 1) Anal pap smear with abnormal results were compared based on participants viral status, and among those MSM HIV (+) the prevalence was 11.5%, and in TW HIV (+) 55.5%, in MSM HIV (-) was 11.7%, and in TW HIV (-) 4.8%. Comparison of pap abnormalities, and High-risk HPV (HR-HPV), revealed that in both HIV (+) and (-) TW all were linked to HR-HPV, with 83.3-88.8% in MSM, and in TW a 100%. (Figure 3)Among these HR-HPV genotypes, HPV 51 was present in 20% in TW, and 22% in MSM. (Figure 3)
Conclusions: HIV seroprevalence was similar in TW population as some estimates (CDC, 2011), but slightly greater in MSM. In our study, HIV and abnormal anal pap results in TW was found exaggeratedly higher with 55.5% among those HIV (+), and only 11.7% in MSM, but also we noted that the presence of HR-HPV in TW was 100%, compared with a range of 83.3-88.8% among MSM. The finding of HPV51 prevalence and the finding of abnormal pap results open a question mark, about if this genotype is the mainly cause of HPV-related cancer in TW/MSM population.

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