THAC0402 - Oral Abstract Session
Trends in HIV-1 incidence during an outbreak among injecting drug users in Athens, Greece: results of a serobehavioral survey (ARISTOTLE program)
Presented by Vana Sypsa (Greece).
V. Sypsa1, G. Nikolopoulos2, D. Paraskevis1, A. Katsoulidou1, M. Kantzanou1, M. Psichogiou3, A. Pharris4, L. Wiessing5, M. Donoghoe6, S. Friedman7, D. Des Jarlais8, M. Malliori3, A. Hatzakis1
1University of Athens, Dept. of Hygiene, Epidemiology and Medical Statistics, Athens, Greece, 2IAS/NIDA Fellow, Hellenic Center for Diseases Control and Prevention, Athens, Greece, 3University of Athens, Athens, Greece, 4European Centre for Disease Prevention and Control, Stockholm, Sweden, 5European Monitoring Centre for Drugs and Drug Addiction, Lisbon, Portugal, 6World Health Organization-Regional Office for Europe, Copenhagen, Denmark, 7National Development and Research Institutes, New York, United States, 8Beth Israel Medical Center, New York, United States
Background: The “ARISTOTLE”
program was implemented in response to the HIV-1 outbreak documented among
injecting drug users (IDUs) in Athens,
2011. The serobehavorial data collected during the program have been used to
assess the trends in HIV-1 incidence and discuss the impact of the
Methods: During August
2012-December 2013, respondent driven sampling was used to recruit IDUs in Athens, Greece.
We conducted five rounds recruiting approximately 1,400 IDUs per round. In
total, 3,320 unique IDUs participated; approximately half of them participated in
multiple rounds. The program consisted
of collection of behavioral data, access to provision of prevention materials
and information, HIV testing and linkage to ART and opioid substitution
treatment (OST). Trends in HIV-1 incidence during the program were assessed both
by assessing seroconversions among IDUs with multiple samples (N=1517) and by
testing HIV(+) samples with LAg-Avidity
EIA to identify recent infections.
Results: During the program, there
were 45 seroconversions. It is estimated that HIV-1 incidence declined by 75%-90%. During the same period, there was a scale-up of
OST services in Athens.
The proportion of participants who reported being on OST increased from 10.4%
in round A to 20.7% in round E. In all rounds, OST coverage was higher among
IDUs who had participated in ARISTOTLE in the past as compared to first-time
participants (e.g. in round E: 22.3% vs. 15.1%, respectively, p=0.006). During
that period, there was no scale-up of needle and syringe programs (% of IDUs
who reported having received free syringes in the previous 30 days: 50.7% in
round A vs. 36.8% in round E, p< 0.001).
Conclusions: During ARISTOTLE
program, a large decline in HIV-1 incidence was observed. Multiple factors may
have played a role including scale-up of HIV-testing and OST, and reductions in
risk behavior as IDUs learned about the epidemic. The program was specifically
designed to promote these factors and achieved a high coverage of the target
population. Although separating out the effect of ARISTOTLE is not
straightforward, data corroborate its impact on preventing transmission.
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